Study on the Mechanism of Ginkgo Seeds in Treating Bronchitis by Network Pharmacology

In recent years, with the global environmental deterioration and air pollution, incidence of bronchitis has increased year by year, sales anti-bronchitis drugs are growing rapidly, mainly due to long treatment cycle difficulty curing. Developing available traditional Chinese medicines significant curative effect against would be a promising strategy; for instance, Ginkgo seeds, as fruit natural plant ginkgo, been used in ancient times cure coughs. However, detailed mechanism curing cough not shown yet. Investigate Semen establishing series molecular networks including active ingredients-targets, proteins interactions, biological functions, pathway, processes targets. this study, main ingredients seeds potential targets related could obtained retrieving corresponding database. The docking study between molecules protein was performed Glide 6.6. Subsequently, total forty were manually selected. Based on this, ingredients-target network constructed using Cytoscape software, well interactions combing String Finally, function, metabolic these analyzed Clue GO plug-in. results indicated that closely lipid transport, positive regulation DNA replication, cAMP other processes, which played vital role mediating interleukin 17, fluid shear stress atherosclerosis, asthma, renin secretion, p53, signaling pathways. Among targets, two ALB (Albumin) DHRS2 (Dehydrogenase 2) can interact compounds more frequently, top three ranked scores amentoflavone, (+)-catechin-5-O-glucoside, liquiritin, implying might bronchitis. It is obvious pharmacological displayed characteristic multi-components, multi-targets, multi-pathways. Nevertheless, derived from further explanation This research provide scientific basis studying seeds.